Throughout the production of APIs (active pharmaceutical ingredients), meeting high yield and high purity during the purification step still represents a tremendous challenge. On the other hand, demands for large batch sizes of peptide APIs are steadily increasing. In particular, if impurities cannot be separated efficiently from the API product, innovations in new, more efficient purification methods are required. These innovations are needed to keep the costs of goods low and contribute to a reduced environmental footprint of the purification process.
Therefore, Bachem implemented an innovative process for large-scale GMP purification, MCSGP, Multicolumn Countercurrent Solvent Gradient Purification. Our new technology provides attractive economic benefits by increasing capacity, with lower solvent consumption.