Oral Presentation 8th Modern Solid Phase Peptide Synthesis & Its Applications Symposium 2022

Empowering proline-rich antimicrobial peptide with bifunctional linkers (#30)

Wenyi Li 1 , John D. Wade 1 , Neil O'Brien-Simpson 1
  1. The University of Melbourne, Melbourne, VIC, Australia
Publish consent withheld
  1. Klein, E. Y.; Milkowska-Shibata, M.; Tseng, K. K.; Sharland, M.; Gandra, S.; Pulcini, C.; Laxminarayan, R. Assessment of WHO antibiotic consumption and access targets in 76 countries, 2000-15: an analysis of pharmaceutical sales data. Lancet Infect Dis, DOI:10.1016/S1473-3099(20)30332-7 10.1016/S1473-3099(20)30332-7.
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  6. Li, W.; O'Brien-Simpson, N. M.; Yao, S.; Tailhades, J.; Reynolds, E. C.; Dawson, R. M.; Otvos, L.; Hossain, M. A.; Separovic, F.; Wade, J. D. C-terminal modification and multimerization increase the efficacy of a proline-rich antimicrobial peptide. Chem. Eur. J. 2017, 23, 390.
  7. Li, W.; O’Brien-Simpson, N. M.; Tailhades, J.; Pantarat, N.; Dawson, R. M.; Otvos, L., Jr.; Reynolds, E. C.; Separovic, F.; Hossain, M. A.; Wade, J. D. Multimerization of a proline-rich antimicrobial peptide, Chex-Arg20, alters its mechanism of interaction with the Escherichia coli membrane. Chem. Biol. 2015, 22 (9), 1250.
  8. Li, W.; Lin, F.; Hung, A.; Barlow, A.; Sani, M.-A.; Paolini, R.; Singleton, W.; Holden, J.; Hossain, M. A.; Separovic, F.et al. Enhancing proline-rich antimicrobial peptide action by homodimerization: Influence of bifunctional linker. Chem. Sci. 2022, DOI:10.1039/d1sc05662j 10.1039/d1sc05662j.