Oral Presentation 8th Modern Solid Phase Peptide Synthesis & Its Applications Symposium 2022

Twists and turns: Using stereoselective fluorination to control peptide conformation (#18)

Luke Hunter 1
  1. School of Chemistry, The University of New South Wales (UNSW), Sydney, NSW, Australia

The biological functions of peptides are intricately linked to their conformations.1 For the past several years, my research group at UNSW has been exploring stereoselective fluorination as a strategy for controlling the conformations of amino acids and peptides, and we have also been investigating potential medicinal applications of these shape-controlled molecules. In this talk I will highlight some of our recently-published work in these areas,2–3 and I will also share details of ongoing projects and future ideas.

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  1. Jwad, R.; Weissberger, D.; Hunter, L. Chem. Rev. 2020, 120, 9743–9789.
  2. Lawer, A.; Hunter, L. Eur. J. Org. Chem. 2021, 1184–1190.
  3. Lawer, A.; Nesvaderani, J.; Marcolin, G. M.; Hunter, L. Tetrahedron 2018, 74, 1278–1287.